Key Publications

Midkine promotes NETosis in myocarditis. Lim GB. (2019) Nat Rev Cardiol. 16:132.

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. Weckbach LT, et al (2019) J Exp Med. 216:350-368

Midkine, a middle manager of β2 integrins. Herter JM, Mayadas TN. (2014) Blood. 123:1777

The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18). Weckbach LT, ….., Walzog B. (2014) Blood. 123:1887

Involvement of midkine in autoimmune and autoinflammatory diseases. Aynacıoğlu AŞ, Bilir A, Tuna MY. (2019) Mod Rheumatol. 29:567-571

From top to bottom: midkine and pleiotrophin as emerging players in immune regulation. Sorrelle N, Dominguez ATA, Brekken RA. (2017) J Leukoc Biol. 102:277-286

Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis. Masuda T, Maeda K, ……… Kadomatsu K. (2017) Am J Pathol. 187:740-751

Midkine and multiple sclerosis. Takeuchi H. (2014) Br J Pharmacol. 171:931-5.

Midkine as a regulator of B cell survival in health and disease. Cohen S, Shachar I. (2014) Br J Pharmacol. 171:888-95.

Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells. Sonobe Y, et al (20102) J Immunol. 188:2602-11.

Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population. Wang J, et al (2008) Proc Natl Acad Sci U S A. 105:3915-20

Diagnostic value of the serum Midkine in patients with rheumatoid arthritis. Abdel Ghafar MT, et al (2019) J Investig Med.  pii: jim-2019-001097. doi: 10.1136/jim-2019-001097.

Serum Midkine Levels in Systemic Lupus Erythematosus. Marpaung B, Ginting AR, Sjah OM. (2018) Maced J Med Sci. 6:1323-1327

Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis. Rice LM, et al (2018) Arthritis Res Ther. 20:185.

Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus. Wu GC, Yuan H, Pan HF, Ye DQ. (2017) Oncotarget. 8:40181-40189.

Influence of Menopause on Inflammatory Cytokines during Murine and Human Bone Fracture Healing. Fischer V, … , Lieder A, Haffner-Luntzer M (2018). Int J Mol Sci. 19:E2070.

The inflammatory phase of fracture healing is influenced by oestrogen status in mice. Haffner-Luntzer M,…., Liedert A, Ignatius A. (2017) Eur J Med Res.22:23.

Inhibition of Midkine Augments Osteoporotic Fracture Healing. Haffner-Luntzer M, ….., Ignatius A, Liedert A (2016) PLoS One. 2016 11:e0159278.

Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus. Haffner-Luntzer M,….., Liedert A (2016) Br J Pharmacol. 173:2237-4.

The role of midkine in skeletal remodelling. Liedert A, Schinke T, Ignatius A, Amling M (2014). Br J Pharmacol. 171:870.

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. Haffner-Luntzer M, …..Amling M, Ignatius A, Liedert A. (2014) PLoS One 9:e116282.

Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading. Liedert A, ……Amling M, Ignatius A (2011) Bone. 2011 48:945

The Role of Midkine in Arteriogenesis, Involving Mechanosensing, Endothelial Cell Proliferation, and Vasodilation. Weckbach LT, Preissner KT, Deindl E. (2018) Int J Mol Sci. 19: pii: E2559.

Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3. Lautz T et al, (2018) EBioMedicine. 27:237-246.

Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice. Takemoto Y, et al (2017) Circ J. 82:19.

Involvement of Endothelial Nitric Oxide Synthase Activation in Midkine-Mediated Central Hypotensive Effects. Lin CH, et al (2017) Chin J Physiol. 60:353-362.

Midkine's Role in Cardiac Pathology. Woulfe KC, Sucharov CC. (2017) J Cardiovasc Dev Dis. 4. pii:13.

Midkine Deteriorates Cardiac Remodeling via Epidermal Growth Factor Receptor Signaling in Chronic Kidney Disease. Honda Y, et al (2016) Hypertension. 67:857-65.

Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation. Bargehr J, et al (2016) Stem Cells Transl Med. 2016 Jul;5(7):946-59.

The growth factor midkine regulates the renin-angiotensin system in mice. Hobo A, et al (2009). J Clin Invest. 119:1616-25.

Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts. Banno H, et al (2006) J Vasc Surg. 44:633-41

Neointima formation in a restenosis model is suppressed in midkine-deficient mice. Horiba M, et al. (2000) J Clin Invest. 105:489-95

Performance of a clinical/proteomic panel to predict obstructive peripheral artery disease in patients with and without diabetes mellitus. McCarthy CP, et al. (2019) Open Heart. 6:e000955.

A clinical and proteomics approach to predict the presence of obstructive peripheral arterial disease: From the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) Study. McCarthy CP, et al. (2018) Clin Cardiol. 41:903-909

Midkine levels and its relationship with atherosclerotic risk factors in essential hypertensive patients. Guzel S, et al. (2018) Niger J Clin Pract. 21:894-900.

A Clinical and Biomarker Scoring System to Predict the Presence of Obstructive Coronary Artery Disease. Ibrahim NE, et al (2017) J Am Coll Cardiol. 69:1147-1156

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTPβ/ζ Axis: Relevance in Therapeutic Development. Herradon G, Ramos-Alvarez MP, Gramage E. (2019) Front Pharmacol. 10:377.

Leukocyte receptor tyrosine kinase interacts with secreted midkine to promote survival of migrating neural crest cells. Vieceli FM, Bronner ME. (2018) Development. 145: pii: dev164046.

Endogenous pleiotrophin and midkine regulate LPS-induced glial responses. Fernández-Calle R, ……, Herradón G. (2018) Neurosci Lett. 662:213-218

Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Fernández-Calle R, et al. (2018) Neuropharmacology. 137:86.

Involvement of midkine in the development of pulmonary fibrosis. Misa K, et al (2017) Physiol Rep. 5 pii: e13383.

Elevated Serum Midkine in Patients With Acute Pancreatitis. Li Y, Lu Y, Shen J, Xu C. (2017) Am J Med Sci. 354:548-552

Urine and serum midkine levels in an Australian chronic kidney disease clinic population: an observational study. Campbell VK, et al. (2017) BMJ Open. 7:e014615

Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression. Chen H, He D, Lasek AW. (2017) Genes Brain Behav.16:699-708

Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine. Vicente-Rodríguez M, ……Herradón G. (2016) Mediators Inflamm. 2016:9894504

Midkine in nephrogenesis, hypertension and kidney diseases. Sato W, Sato Y. (2014) Br J Pharmacol. 171:879-87

Midkine and Melanoma Metastasis: A Malevolent Mix. Karaman S, Alitalo K. (2017) Dev Cell. 42:205.

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine. Olmeda D, et al (2017) Nature. 546:676-680